Ontology highlight
ABSTRACT:
SUBMITTER: Oliveira TPD
PROVIDER: S-EPMC7902877 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Oliveira Tadeu P D TPD Gonçalves Bruno D C BDC Oliveira Bruna S BS de Oliveira Antonio Carlos P ACP Reis Helton J HJ Ferreira Claudia N CN Aguiar Daniele C DC de Miranda Aline S AS Ribeiro Fabiola M FM Vieira Erica M L EML Palotás András A Vieira Luciene B LB
Frontiers in neuroscience 20210210
Obesity is a multifactorial disease, which in turn contributes to the onset of comorbidities, such as diabetes and atherosclerosis. Moreover, there are only few options available for treating obesity, and most current pharmacotherapy causes severe adverse effects, while offering minimal weight loss. Literature shows that metabotropic glutamate receptor 5 (mGluR5) modulates central reward pathways. Herein, we evaluated the effect of VU0409106, a negative allosteric modulator (NAM) of mGluR5 in re ...[more]