Mendelian randomization for studying the effects of perturbing drug targets.
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ABSTRACT:
SUBMITTER: Gill D
PROVIDER: S-EPMC7903200 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Mendelian randomization for studying the effects of perturbing drug targets.
Gill Dipender D Georgakis Marios K MK Walker Venexia M VM Schmidt A Floriaan AF Gkatzionis Apostolos A Freitag Daniel F DF Finan Chris C Hingorani Aroon D AD Howson Joanna M M JMM Burgess Stephen S Swerdlow Daniel I DI Davey Smith George G Holmes Michael V MV Dichgans Martin M Scott Robert A RA Zheng Jie J Psaty Bruce M BM Davies Neil M NM
Wellcome open research 20210210
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that encode drug targets can be used in Mendelian randomization analyses to offer insight into mechanism-based efficacy and adverse effects. Large databases of summary level genetic association data are increasingly available and can be leveraged to identify and validate variants th ...[more]
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