Ontology highlight
ABSTRACT:
SUBMITTER: Conn CE
PROVIDER: S-EPMC7903247 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Conn Charlotte E CE de Campo Liliana L Whitten Andrew E AE Garvey Christopher J CJ Krause-Heuer Anwen M AM van 't Hag Leonie L
Frontiers in chemistry 20210209
This perspective describes advances in determining membrane protein structures in lipid bilayers using small-angle neutron scattering (SANS). Differentially labeled detergents with a homogeneous scattering length density facilitate contrast matching of detergent micelles; this has previously been used successfully to obtain the structures of membrane proteins. However, detergent micelles do not mimic the lipid bilayer environment of the cell membrane <i>in vivo</i>. Deuterated vesicles can be us ...[more]