CausalBuilder: bringing the MI2CAST causal interaction annotation standard to the curator.

ABSTRACT: Molecular causal interactions are defined as regulatory connections between biological components. They are commonly retrieved from biological experiments and can be used for connecting biological molecules together to enable the building of regulatory computational models that represent biological systems. However, including a molecular causal interaction in a model requires assessing its relevance to that model, based on the detailed knowledge about the biomolecules, interaction type and biological context. In order to standardize the representation of this knowledge in 'causal statements', we recently developed the Minimum Information about a Molecular Interaction Causal Statement (MI2CAST) guidelines. Here, we introduce causalBuilder: an intuitive web-based curation interface for the a

SUBMITTER: Toure V 

PROVIDER: S-EPMC7904049 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature