When to wake up? The optimal waking-up strategies for starvation-induced persistence.

ABSTRACT: Prolonged lag time can be induced by starvation contributing to the antibiotic tolerance of bacteria. We analyze the optimal lag time to survive and grow the iterative and stochastic application of antibiotics. A simple model shows that the optimal lag time can exhibit a discontinuous transition when the severeness of the antibiotic application, such as the probability to be exposed the antibiotic, the death rate under the exposure, and the duration of the exposure, is increased. This suggests the possibility of reducing tolerant bacteria by controlled usage of antibiotics application. When the bacterial populations are able to have two phenotypes with different lag times, the fraction of the second phenotype that has different lag time shows a continuous transition. We then present a gene

SUBMITTER: Himeoka Y 

PROVIDER: S-EPMC7904209 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature