Dataset Information

Supplementation with milk enriched with complex lipids during pregnancy: A double-blind randomized controlled trial.

ABSTRACT:

Background

Gangliosides are a class of sphingolipids that are present in the cell membranes of vertebrates. Gangliosides influence a broad range of cellular processes through effects on signal transduction, being found abundantly in the brain, and having a role in neurodevelopment.

Objective

We aimed to assess the effects of maternal daily consumption of ganglioside-enriched milk vs non-enriched milk and a non-supplemented group of pregnant women on maternal ganglioside levels and pregnancy outcomes.

Design

Double-blind parallel randomized controlled trial.

Methods

1,500 women aged 20-40 years were recruited in Chongqing (China) between 11 and 14 weeks of a singleton pregnancy, and randomized into three groups: Control-received standard powdered milk formulation (?4 mg gangliosides/day); Complex milk lipid-enhanced (CML-E) group-same formulation enriched with complex milk lipids (?8 mg gangliosides/day) from milk fat globule membrane; Reference-received no milk. Serum ganglioside levels were measured in a randomly selected subsample of 250 women per group.

Results

CML-E milk was associated with marginally greater total gangliosides levels in maternal serum compared to Control (13.02 vs 12.69 ?g/ml; p = 0.034) but not to Reference group. CML-E milk did not affect cord blood ganglioside levels. Among the 1500 women, CML-E milk consumption was associated with a lower rate of gestational diabetes mellitus than control milk [relative risk 0.80 (95% CI 0.64, 0.99)], but which was not different to the Reference group. CML-E milk supplementation had no other effects on maternal or newborn health.

Conclusions

Maternal supplementation with milk fat globule membrane, as a source of gangliosides, was not associated with any adverse health outcomes, and did not increase serum gangliosides compared with the non-supplemented reference group.

Trial registration

Chinese Clinical Trial Register (ChiCTR-IOR-16007700).

Clinical trial registration

ChiCTR-IOR-16007700; www.chictr.org.cn/showprojen.aspx?proj=12972.

SUBMITTER: Albert BB

PROVIDER: S-EPMC7904220 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Supplementation with milk enriched with complex lipids during pregnancy: A double-blind randomized controlled trial.

Albert Benjamin B BB Derraik José G B JGB Xia Yin-Yin YY Norris Tom T Zhang Ting T Han Ting-Li TL Chang Chen C Rowan Angela A Gallier Sophie S Souza Renato T RT Hammond Judith J JJ Zhou Wei W Zhang Hua H Qi Hong-Bo HB Baker Philip N PN

PloS one 20210224 2

<h4>Background</h4>Gangliosides are a class of sphingolipids that are present in the cell membranes of vertebrates. Gangliosides influence a broad range of cellular processes through effects on signal transduction, being found abundantly in the brain, and having a role in neurodevelopment.<h4>Objective</h4>We aimed to assess the effects of maternal daily consumption of ganglioside-enriched milk vs non-enriched milk and a non-supplemented group of pregnant women on maternal ganglioside levels and ...[more]

PMID: 33626041

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Dataset Information

Supplementation with milk enriched with complex lipids during pregnancy: A double-blind randomized controlled trial.

Background

Objective

Design

Methods

Results

Conclusions

Trial registration

Clinical trial registration

Publications

Supplementation with milk enriched with complex lipids during pregnancy: A double-blind randomized controlled trial.

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