Ontology highlight
ABSTRACT:
SUBMITTER: Huot N
PROVIDER: S-EPMC7904927 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Huot Nicolas N Rascle Philippe P Petitdemange Caroline C Contreras Vanessa V Stürzel Christina M CM Baquero Eduard E Harper Justin L JL Passaes Caroline C Legendre Rachel R Varet Hugo H Madec Yoann Y Sauermann Ulrike U Stahl-Hennig Christiane C Nattermann Jacob J Saez-Cirion Asier A Le Grand Roger R Keith Reeves R R Paiardini Mirko M Kirchhoff Frank F Jacquelin Beatrice B Müller-Trutwin Michaela M
Nature communications 20210224 1
Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues. We demonstrate that SIVagm infection induces the expansion of terminally differentiated NKG2a<sup>low</sup> NK cells in secondary lymphoid organs displaying an adaptive transcriptional profile and increased MHC-E-restricted cytotoxicity in response to SIV Env pept ...[more]