Ontology highlight
ABSTRACT:
SUBMITTER: Tiffner A
PROVIDER: S-EPMC7905104 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Tiffner Adéla A Maltan Lena L Fahrner Marc M Sallinger Matthias M Weiß Sarah S Grabmayr Herwig H Höglinger Carmen C Derler Isabella I
Frontiers in cell and developmental biology 20210211
STIM1-mediated activation of calcium selective Orai channels is fundamental for life. The three Orai channel isoforms, Orai1-3, together with their multiple ways of interplay, ensure their highly versatile role in a variety of cellular functions and tissues in both, health and disease. While all three isoforms are activated in a store-operated manner by STIM1, they differ in diverse biophysical and structural properties. In the present study, we provide profound evidence that non-conserved resid ...[more]