Ontology highlight
ABSTRACT:
SUBMITTER: Ryzhikov AB
PROVIDER: S-EPMC7905424 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Ryzhikov Alexandr B AB Onkhonova Galina S GS Imatdinov Ilnaz R IR Gavrilova Elena V EV Maksyutov Rinat A RA Gordeeva Elena A EA Pazynina Galina V GV Ryzhov Ivan M IM Shilova Nadezhda V NV Bovin Nicolai V NV
Biochemistry. Biokhimiia 20210301 3
Many viruses, beside binding to their main cell target, interact with other molecules that promote virus adhesion to the cell; often, these additional targets are glycans. The main receptor for SARS-CoV-2 is a peptide motif in the ACE2 protein. We studied interaction of the recombinant SARS-CoV-2 spike (S) protein with an array of glycoconjugates, including various sialylated, sulfated, and other glycans, and found that the S protein binds some (but not all) glycans of the lactosamine family. We ...[more]