Ontology highlight
ABSTRACT:
SUBMITTER: Gong ZH
PROVIDER: S-EPMC7906188 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Gong Zhen-Hua ZH Ji Jiang J Yao Jian J Ji Jian-Feng JF Jiang Yasu Y Gao Gang G Feng Zhou Z
Aging 20210119 3
Sphingosine kinase 1 (SphK1) is overexpressed in skin squamous cell carcinoma (SCC). It has emerged as a novel therapeutic oncotarget. The current study identified a novel SphK1-targeting microRNA, microRNA-6784 (miR-6784). Here, we show that miR-6784 is located at the cytoplasm of A431 skin SCC cells. It directly binds to <i>SphK1</i> mRNA. Ectopic overexpression of miR-6784 inhibited <i>SphK1</i> 3'-untranslated region (UTR) luciferase activity and downregulated its expression. Moreover, miR-6 ...[more]