Dataset Information

The cost-effectiveness of prostate cancer screening using the Stockholm3 test.

ABSTRACT:

Objectives

The European Randomized Study of Screening for Prostate Cancer found that prostate-specific antigen (PSA) screening reduced prostate cancer mortality, however the costs and harms from screening may outweigh any mortality reduction. Compared with screening using the PSA test alone, using the Stockholm3 Model (S3M) as a reflex test for PSA ? 1 ng/mL has the same sensitivity for Gleason score ? 7 cancers while the relative positive fractions for Gleason score 6 cancers and no cancer were 0.83 and 0.56, respectively. The cost-effectiveness of the S3M test has not previously been assessed.

Methods

We undertook a cost-effectiveness analysis from a lifetime societal perspective. Using a microsimulation model, we simulated for: (i) no prostate cancer screening; (ii) screening using the PSA test; and (iii) screening using the S3M test as a reflex test for PSA values ? 1, 1.5 and 2 ng/mL. Screening strategies included quadrennial re-testing for ages 55-69 years performed by a general practitioner. Discounted costs, quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICERs) were calculated.

Results

Comparing S3M with a reflex threshold of 2 ng/mL with screening using the PSA test, S3M had increased effectiveness, reduced lifetime biopsies by 30%, and increased societal costs by 0.4%. Relative to the PSA test, the S3M reflex thresholds of 1, 1.5 and 2 ng/mL had ICERs of 170,000, 60,000 and 6,000 EUR/QALY, respectively. The S3M test was more cost-effective at higher biopsy costs.

Conclusions

Prostate cancer screening using the S3M test for men with an initial PSA ? 2.0 ng/mL was cost-effective compared with screening using the PSA test alone.

SUBMITTER: Karlsson AA

PROVIDER: S-EPMC7906342 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

The cost-effectiveness of prostate cancer screening using the Stockholm3 test.

Karlsson Andreas A AA Hao Shuang S Jauhiainen Alexandra A Elfström K Miriam KM Egevad Lars L Nordström Tobias T Heintz Emelie E Clements Mark S MS

PloS one 20210225 2

<h4>Objectives</h4>The European Randomized Study of Screening for Prostate Cancer found that prostate-specific antigen (PSA) screening reduced prostate cancer mortality, however the costs and harms from screening may outweigh any mortality reduction. Compared with screening using the PSA test alone, using the Stockholm3 Model (S3M) as a reflex test for PSA ≥ 1 ng/mL has the same sensitivity for Gleason score ≥ 7 cancers while the relative positive fractions for Gleason score 6 cancers and no can ...[more]

PMID: 33630863

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Dataset Information

The cost-effectiveness of prostate cancer screening using the Stockholm3 test.

Objectives

Methods

Results

Conclusions

Publications

The cost-effectiveness of prostate cancer screening using the Stockholm3 test.

Similar Datasets

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