Ontology highlight
ABSTRACT:
SUBMITTER: Michie MS
PROVIDER: S-EPMC7906437 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20170901 36
Far-red cyanine fluorophores find extensive use in modern microscopy despite modest quantum yields. To improve the photon output of these molecules, we report a synthetic strategy that blocks the major deactivation pathway: excited-state trans-to-cis polyene rotation. In the key transformation, a protected dialdehyde precursor undergoes a cascade reaction to install the requisite tetracyclic ring system. The resulting molecules exhibit the characteristic features of conformational restraint, inc ...[more]