Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC7906906 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Zhang Xin X Liu Yi Y Dai Lei L Shi Gang G Deng Jie J Luo Qiang Q Xie Qian Q Cheng Lin L Li Chunlei C Lin Yi Y Wang Qingnan Q Fan Ping P Zhang Hantao H Su Xiaolan X Zhang Shuang S Yang Yang Y Hu Xun X Gong Qiyong Q Yu Dechao D Zheng Lei L Deng Hongxin H
Oncogene 20210115 8
The basic leucine zipper ATF-like transcription factor 2 (BATF2) has been implicated in inflammatory responses and anti-tumour effects. Little, however, is known regarding its extracellular role in maintaining a non-supportive cancer microenvironment. Here, we show that BATF2 inhibits glioma growth and myeloid-derived suppressor cells (MDSCs) recruitment. Interestingly, extracellular vesicles (EVs) from BATF2-overexpressing glioma cell lines (BATF2-EVs) inhibited MDSCs chemotaxis in vitro. Moreo ...[more]