Dataset Information

Effects of oral moisturizing gel containing propolis following head and neck radiotherapy: randomized controlled pilot trial.

ABSTRACT:

Aim

Topical administration of oral gel may reduce radiotherapy-related oral complications. The aim of this study was to examine clinical and microbiological effects of self-administration of different gel formulations to oral mucosa in head and neck cancer patients.

Materials and methods

Twenty-seven subjects were recruited from outpatients who underwent radiotherapy of at least 50?Gy to the head and neck area. They were randomly assigned to oral gel with the following different ingredients: placebo, chlorhexidine, curry leaf, propolis, and turmeric. Before and after intervention, oral symptoms were evaluated, and nine oral pathogens in saliva were also quantified using real-time PCR.

Results

Twenty-five subjects completed the study and their data were analyzed. The number of Porphyromonas gingivalis in saliva significantly decreased after treatment with propolis gel, but not after any other treatments. Propolis gel treatment also relieved oral pain in all subjects who had oral pain at the baseline.

Conclusions

Topical administration with propolis gel may not only reduce P. gingivalis carriage in saliva, but also relieve oral pain.

Discussion

A future larger-scale clinical trial of oral propolis gel is needed to determine its clinical efficacy in radiotherapy-related oral complications of head and neck cancer patients.

SUBMITTER: Nakao R

PROVIDER: S-EPMC7907078 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Effects of oral moisturizing gel containing propolis following head and neck radiotherapy: randomized controlled pilot trial.

Nakao Ryoma R Ueno Takao T

BDJ open 20210225 1

<h4>Aim</h4>Topical administration of oral gel may reduce radiotherapy-related oral complications. The aim of this study was to examine clinical and microbiological effects of self-administration of different gel formulations to oral mucosa in head and neck cancer patients.<h4>Materials and methods</h4>Twenty-seven subjects were recruited from outpatients who underwent radiotherapy of at least 50 Gy to the head and neck area. They were randomly assigned to oral gel with the following different i ...[more]

PMID: 33633111

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Project description:BackgroundTo evaluate and establish a digital workflow for the custom designing and 3D printing of mouth opening tongue-depressing (MOTD) stents for patients receiving radiotherapy for head and neck cancer.MethodsWe retrospectively identified 3 patients who received radiation therapy (RT) for primary head and neck cancers with MOTD stents. We compared two methods for obtaining the digital impressions of patients' teeth. The first method involved segmentation from computed tomography (CT) scans, as previously established by our group, and the second method used 3D scanning of the patients' articulated stone models that were made during the conventional stent fabrication process. Three independent observers repeated the process to obtain digital impressions which provided data to design customized MOTD stents. For each method, we evaluated the time efficiency, dice similarity coefficient (DSC) for reproducibility, and the 3D printed stents' accuracy. For the 3D scanning method, we evaluated the registration process using manual and automatic approaches.ResultsFor all patients, the 3D scanning method demonstrated a significant advantage over the CT scanning method in terms of time efficiency with over 60% reduction in time consumed (p < 0.0001) and reproducibility with significantly higher DSC (p < 0.001). The printed stents were tested over the articulated dental stone models, and the trueness of fit and accuracy of dental anatomy was found to be significantly better for MOTD stents made using the 3D scanning method. The automated registration showed higher accuracy with errors < 0.001 mm compared to manual registration.ConclusionsWe developed an efficient workflow for custom designing and 3D-printing MOTD radiation stents. This workflow represents a considerable improvement over the CT-derived segmentation method. The application of this rapid and efficient digital workflow into radiation oncology practices can expand the use of these toxicity sparing devices to practices that do not currently have the support to make them.

Dataset Information

Effects of oral moisturizing gel containing propolis following head and neck radiotherapy: randomized controlled pilot trial.

Aim

Materials and methods

Results

Conclusions

Discussion

Publications

Effects of oral moisturizing gel containing propolis following head and neck radiotherapy: randomized controlled pilot trial.

Similar Datasets

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