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Guapiacu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil.


ABSTRACT: Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative dISFV, termed Guapiaçu virus (GUAPV). Distinct strains of GUAPV were isolated from pools of Aedes terrens and Aedes scapularis mosquitoes. Additionally, we also detected viral GUAPV RNA in a plasma sample of an individual febrile from the Amazon region (North of Brazil). Although GUAPV did not replicate in tested mammalian cells, 3'UTR secondary structures duplication and codon usage index were similar to pathogenic flavivirus.

SUBMITTER: de Oliveira Ribeiro G 

PROVIDER: S-EPMC7907106 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil.

de Oliveira Ribeiro Geovani G   da Costa Antonio Charlys AC   Gill Danielle Elise DE   Ribeiro Edcelha Soares D'Athaide ESD   Rego Marlisson Octavio da S MODS   Monteiro Fred Julio Costa FJC   Villanova Fabiola F   Nogueira Juliana Silva JS   Maeda Adriana Yurika AY   de Souza Renato Pereira RP   Tahmasebi Roozbeh R   Morais Vanessa S VS   Pandey Ramendra Pati RP   Raj V Samuel VS   Scandar Sirle Abdo Salloum SAS   da Silva Vasami Fernanda Gisele FG   D'Agostino Leandro Guaraglia LG   Maiorka Paulo César PC   Deng Xutao X   Nogueira Maurício Lacerda ML   Sabino Ester Cerdeira EC   Delwart Eric E   Leal Élcio É   Cunha Mariana Sequetin MS  

Scientific reports 20210225 1


Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying princ  ...[more]

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