Ontology highlight
ABSTRACT: Purpose
To develop and validate a machine learning model based on radiomic features derived from 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) images to preoperatively predict the pathological grade in patients with pancreatic ductal adenocarcinoma (PDAC).Methods
A total of 149 patients (83 men, 66 women, mean age 61 years old) with pathologically proven PDAC and a preoperative 18F-FDG PET/CT scan between May 2009 and January 2016 were included in this retrospective study. The cohort of patients was divided into two separate groups for the training (99 patients) and validation (50 patients) in chronological order. Radiomics features were extracted from PET/CT images using Pyradiomics implemented in Python, and the XGBoost algorithm was used to build a prediction model. Conventional PET parameters, including standardized uptake value, metabolic tumor volume, and total lesion glycolysis, were also measured. The quality of the proposed model was appraised by means of receiver operating characteristics (ROC) and areas under the ROC curve (AUC).Results
The prediction model based on a twelve-feature-combined radiomics signature could stratify PDAC patients into grade 1 and grade 2/3 groups with AUC of 0.994 in the training set and 0.921 in the validation set.Conclusion
The model developed is capable of predicting pathological differentiation grade of PDAC based on preoperative 18F-FDG PET/CT radiomics features.
SUBMITTER: Xing H
PROVIDER: S-EPMC7907291 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Xing Haiqun H Hao Zhixin Z Zhu Wenjia W Sun Dehui D Ding Jie J Zhang Hui H Liu Yu Y Huo Li L
EJNMMI research 20210225 1
<h4>Purpose</h4>To develop and validate a machine learning model based on radiomic features derived from <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography/computed tomography (PET/CT) images to preoperatively predict the pathological grade in patients with pancreatic ductal adenocarcinoma (PDAC).<h4>Methods</h4>A total of 149 patients (83 men, 66 women, mean age 61 years old) with pathologically proven PDAC and a preoperative <sup>18</sup>F-FDG PET/CT scan betwe ...[more]