Suppression of ELF4 in ulcerative colitis predisposes host to colorectal cancer.
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ABSTRACT:
SUBMITTER: Du H
PROVIDER: S-EPMC7907480 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Suppression of ELF4 in ulcerative colitis predisposes host to colorectal cancer.
Du Hongqiang H Xia Huawei H Liu Tongtong T Li Yingjie Y Liu Jilong J Xie Bingteng B Chen Jingxuan J Liu Tong T Cao Lili L Liu Shengde S Li Siji S Wang Peiyan P Wang Dandan D Zhang Zeming Z Li Yunfei Y Guo Xiaohuan X Wu Aiwen A Li Mo M You Fuping F
iScience 20210209 3
Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterized by relapsing and remitting colon mucosal inflammation. For patients suffering from UC, a higher risk of colon cancer has been widely recognized. Here, we found that <i>Elf4</i> <sup>-/-</sup> mice developed colon tumors with 3 cycles of dextran sulfate sodium salt (DSS) treatment alone. We further showed that ELF4 suppression was prevalent in both patients with UC and DSS-induced mice models, and this suppression was ...[more]
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