The Role of NLRP3 Inflammasome in Pericarditis: Potential for Therapeutic Approaches.
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ABSTRACT:
SUBMITTER: Mauro AG
PROVIDER: S-EPMC7907621 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
The Role of NLRP3 Inflammasome in Pericarditis: Potential for Therapeutic Approaches.
Mauro Adolfo G AG Bonaventura Aldo A Vecchié Alessandra A Mezzaroma Eleonora E Carbone Salvatore S Narayan Pratyush P Potere Nicola N Cannatà Antonio A Paolini John F JF Bussani Rossana R Montecucco Fabrizio F Sinagra Gianfranco G Van Tassel Benjamin W BW Abbate Antonio A Toldo Stefano S
JACC. Basic to translational science 20210222 2
Human samples of patients with chronic pericarditis and appropriate control subjects were stained for the inflammasome components. A mouse model of pericarditis was developed through the intrapericardial injection of zymosan A. Different inflammasome blockers were tested in the mouse model. Patients with pericarditis presented an intensification of the inflammasome activation compared with control subjects. The experimental model showed the pathological features of pericarditis. Among inflammaso ...[more]
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