Dataset Information

Gastrointestinal mucosal damage in patients with COVID-19 undergoing endoscopy: an international multicentre study.

ABSTRACT: Although evidence suggests frequent gastrointestinal (GI) involvement during coronavirus disease 2019 (COVID-19), endoscopic findings are scarcely reported. We aimed at registering endoscopic abnormalities and potentially associated risk factors among patients with COVID-19. All consecutive patients with COVID-19 undergoing endoscopy in 16 institutions from high-prevalence regions were enrolled. Mann-Whitney U, χ2 or Fisher's exact test were used to compare patients with major abnormalities to those with negative procedures, and multivariate logistic regression to identify independent predictors. Between February and May 2020, during the first pandemic outbreak with severely restricted endoscopy activity, 114 endoscopies on 106 patients with COVID-19 were performed in 16 institutions (men=70.8%, median age=68 (58-74); 33% admitted in intensive care unit; 44.4% reporting GI symptoms). 66.7% endoscopies were urgent, mainly for overt GI bleeding. 52 (45.6%) patients had major abnormalities, whereas 13 bled from previous conditions. The most prevalent upper GI abnormalities were ulcers (25.3%), erosive/ulcerative gastro-duodenopathy (16.1%) and petechial/haemorrhagic gastropathy (9.2%). Among lower GI endoscopies, 33.3% showed an ischaemic-like colitis.Receiver operating curve analysis identified D-dimers >1850 ng/mL as predicting major abnormalities. Only D-dimers >1850 ng/mL (OR=12.12 (1.69-86.87)) and presence of GI symptoms (OR=6.17 (1.13-33.67)) were independently associated with major abnormalities at multivariate analysis. In this highly selected cohort of hospitalised patients with COVID-19 requiring endoscopy, almost half showed acute mucosal injuries and more than one-third of lower GI endoscopies had features of ischaemic colitis. Among the hospitalisation-related and patient-related variables evaluated in this study, D-dimers above 1850 ng/mL was the most useful at predicting major mucosal abnormalities at endoscopy. ClinicalTrial.gov (ID: NCT04318366).

SUBMITTER: Vanella G

PROVIDER: S-EPMC7907837 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Gastrointestinal mucosal damage in patients with COVID-19 undergoing endoscopy: an international multicentre study.

Vanella Giuseppe G Capurso Gabriele G Burti Cesare C Fanti Lorella L Ricciardiello Luigi L Souza Lino Andre A Boskoski Ivo I Bronswijk Michiel M Tyberg Amy A Krishna Kumar Nair Govind G Angeletti Stefano S Mauro Aurelio A Zingone Fabiana F Oppong Kofi W KW de la Iglesia-Garcia Daniel D Pouillon Lieven L Papanikolaou Ioannis S IS Fracasso Pierluigi P Ciceri Fabio F Rovere-Querini Patrizia P Tomba Carolina C Viale Edi E Eusebi Leonardo Henry LH Riccioni Maria Elena ME van der Merwe Schalk S Shahid Haroon H Sarkar Avik A Yoo Jin Woo Gene JWG Dilaghi Emanuele E Speight R Alexander RA Azzolini Francesco F Buttitta Francesco F Porcari Serena S Petrone Maria Chiara MC Iglesias-Garcia Julio J Savarino Edoardo V EV Di Sabatino Antonio A Di Giulio Emilio E Farrell James J JJ Kahaleh Michel M Roelandt Philip P Costamagna Guido G Artifon Everson Luiz de Almeida ELA Bazzoli Franco F Testoni Per Alberto PA Greco Salvatore S Arcidiacono Paolo Giorgio PG

BMJ open gastroenterology 20210201 1

<h4>Background</h4>Although evidence suggests frequent gastrointestinal (GI) involvement during coronavirus disease 2019 (COVID-19), endoscopic findings are scarcely reported.<h4>Aims</h4>We aimed at registering endoscopic abnormalities and potentially associated risk factors among patients with COVID-19.<h4>Methods</h4>All consecutive patients with COVID-19 undergoing endoscopy in 16 institutions from high-prevalence regions were enrolled. Mann-Whitney U, χ<sup>2</sup> or Fisher's exact test we ...[more]

PMID: 33627313

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Project description:The administration of anesthesia during gastrointestinal endoscopy potentially contributes to post-anesthesia cognitive dysfunction (PACD), with detrimental impacts for cognitive function. This study aimed to assess the knowledge, attitudes, and practices (KAP) towards PACD among patients undergoing gastrointestinal endoscopy in Wenzhou region. This cross-sectional study was conducted between June and August 2023, and recruited individuals undergoing gastrointestinal endoscopy. Demographic data and KAP scores were collected through questionnaires. Pearson correlation analysis was applied to evaluate correlations between KAP scores, and logistic regression was utilized to identify influential factors. We collected 405 valid questionnaires, with 54.57% being male and 29.88% aged 31-40 years. Mean KAP scores were 13.99 ± 4.80, 16.19 ± 2.35, and 15.61 ± 2.86, respectively (possible range: 0-16, 0-25, and 0-25). Pearson correlation analysis demonstrated significant positive correlations between knowledge and practice (r = 0.209, P < 0.001), attitude and practice (r = 0.233, P < 0.001), and knowledge and attitude (r = 0.328, P < 0.001). Multivariate logistic regression revealed negative associations of opting for standard gastrointestinal endoscopy (without anesthesia) with knowledge (OR = 0.227, 95%CI: 0.088-0.582, P = 0.002) and practice scores (OR = 0.336, 95%CI: 0.154-0.731, P = 0.006). Additionally, the presence of cognitive-related diseases or symptoms before undergoing gastrointestinal endoscopy was negatively associated with knowledge scores (OR = 0.429, 95%CI: 0.225-0.818, P = 0.010). Patients undergoing gastrointestinal endoscopy demonstrated good knowledge, neutral attitudes, and moderate practices regarding PACD. Educational interventions and behavior modification are recommended, particularly for individuals with lower monthly income, undergoing standard gastrointestinal endoscopy, or experiencing cognitive-related conditions.

Dataset Information

Gastrointestinal mucosal damage in patients with COVID-19 undergoing endoscopy: an international multicentre study.

Publications

Gastrointestinal mucosal damage in patients with COVID-19 undergoing endoscopy: an international multicentre study.

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