Dataset Information
Sex Differences in Cognitive Decline Among US Adults.
Ontology highlight
ABSTRACT: Importance
Sex differences in dementia risk are unclear, but some studies have found greater risk for women.Objective
To determine associations between sex and cognitive decline in order to better understand sex differences in dementia risk.Design, setting, and participants
This cohort study used pooled analysis of individual participant data from 5 cohort studies for years 1971 to 2017: Atherosclerosis Risk in Communities Study, Coronary Artery Risk Development in Young Adults Study, Cardiovascular Health Study, Framingham Offspring Study, and Northern Manhattan Study. Linear mixed-effects models were used to estimate changes in each continuous cognitive outcome over time by sex. Data analysis was completed from March 2019 to October 2020.Exposure
Sex.Main outcomes and measures
The primary outcome was change in global cognition. Secondary outcomes were change in memory and executive function. Outcomes were standardized as t scores (mean [SD], 50 [10]); a 1-point difference represents a 0.1-SD difference in cognition.Results
Among 34?349 participants, 26?088 who self-reported Black or White race, were free of stroke and dementia, and had covariate data at or before the first cognitive assessment were included for analysis. Median (interquartile range) follow-up was 7.9 (5.3-20.5) years. There were 11?775 (44.7%) men (median [interquartile range] age, 58 [51-66] years at first cognitive assessment; 2229 [18.9%] Black) and 14?313 women (median [interquartile range] age, 58 [51-67] years at first cognitive assessment; 3636 [25.4%] Black). Women had significantly higher baseline performance than men in global cognition (2.20 points higher; 95% CI, 2.04 to 2.35 points; P?Conclusions and relevanceThe results of this cohort study suggest that women may have greater cognitive reserve but faster cognitive decline than men, which could contribute to sex differences in late-life dementia.
SUBMITTER: Levine DA
PROVIDER: S-EPMC7907956 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Sex Differences in Cognitive Decline Among US Adults.
JAMA network open 20210201 2
<h4>Importance</h4>Sex differences in dementia risk are unclear, but some studies have found greater risk for women.<h4>Objective</h4>To determine associations between sex and cognitive decline in order to better understand sex differences in dementia risk.<h4>Design, setting, and participants</h4>This cohort study used pooled analysis of individual participant data from 5 cohort studies for years 1971 to 2017: Atherosclerosis Risk in Communities Study, Coronary Artery Risk Development in Young ...[more]