Epigenetics and expression of key genes associated with cardiac fibrosis: NLRP3, MMP2, MMP9, CCN2/CTGF and AGT.
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ABSTRACT:
SUBMITTER: Chandra S
PROVIDER: S-EPMC7907962 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Epigenetics and expression of key genes associated with cardiac fibrosis: <i>NLRP3, MMP2, MMP9, CCN2/CTGF</i> and <i>AGT</i>.
Chandra Sruti S Ehrlich Kenneth C KC Lacey Michelle M Baribault Carl C Ehrlich Melanie M
Epigenomics 20210204 3
<b>Aims:</b> Excessive inflammatory signaling and pathological remodeling of the extracellular matrix drive cardiac fibrosis and require changes in gene expression. <b>Materials and methods:</b> Using bioinformatics, both tissue-specific expression profiles and epigenomic profiles of some genes critical for cardiac fibrosis were examined, namely, <i>NLRP3, MMP2, MMP9, CCN2/CTGF, AGT</i> (encodes angiotensin II precursors) and <i>hsa-mir-223</i> (post-transcriptionally regulates <i>NLRP3</i>). <b ...[more]
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