Ontology highlight
ABSTRACT:
SUBMITTER: Oosthuizen J
PROVIDER: S-EPMC7908826 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in oncology 20210212
Breast cancer patients historically benefitted from population-based genetic research performed in South Africa, which led to the development of founder-based <i>BRCA1/2</i> diagnostic tests. With the advent of next-generation sequencing (NGS) technologies, the clinical utility of limited, targeted genetic assays were questioned. The study focused on mining NGS data obtained from an extensive single-institution NGS series (n=763). The aims were to determine (i) the prevalence of the most common ...[more]