Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Complete Genome Sequence of Campylobacter hepaticus USA52, Associated with Chicken Spotty Liver Disease.

ABSTRACT: Campylobacter hepaticus was recently identified as the etiological agent of chicken spotty liver disease. Here, we report the complete genome sequence of C. hepaticus strain USA52 from the United States. The genome comprises a chromosome of 1,509,100?bp with an average GC content of 28.02%.

SUBMITTER: Wu Z

PROVIDER: S-EPMC7909087 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Complete Genome Sequence of Campylobacter hepaticus USA52, Associated with Chicken Spotty Liver Disease.

Wu Zuowei Z Sahin Orhan O Zhang Qijing Q

Microbiology resource announcements 20210225 8

Campylobacter hepaticus was recently identified as the etiological agent of chicken spotty liver disease. Here, we report the complete genome sequence of C. hepaticus strain USA52 from the United States. The genome comprises a chromosome of 1,509,100 bp with an average GC content of 28.02%. ...[more]

PMID: 33632862

Similar Datasets

Genome Reduction for Niche Association in Campylobacter Hepaticus, A Cause of Spotty Liver Disease in Poultry.

Project description:The term "spotty liver disease" (SLD) has been used since the late 1990s for a condition seen in the UK and Australia that primarily affects free range laying hens around peak lay, causing acute mortality and a fall in egg production. A novel thermophilic SLD-associated Campylobacter was reported in the United Kingdom (UK) in 2015. Subsequently, similar isolates occurring in Australia were formally described as a new species, Campylobacter hepaticus. We describe the comparative genomics of 10 C. hepaticus isolates recovered from 5 geographically distinct poultry holdings in the UK between 2010 and 2012. Hierarchical gene-by-gene analyses of the study isolates and representatives of 24 known Campylobacter species indicated that C. hepaticus is most closely related to the major pathogens Campylobacter jejuni and Campylobacter coli. We observed low levels of within-farm variation, even between isolates collected over almost 3 years. With respect to C. hepaticus genome features, we noted that the study isolates had a ~140 Kb reduction in genome size, ~144 fewer genes, and a lower GC content compared to C. jejuni. The most notable reduction was in the subsystem containing genes for iron acquisition and metabolism, supported by reduced growth of C. hepaticus in an iron depletion assay. Genome reduction is common among many pathogens and in C. hepaticus has likely been driven at least in part by specialization following the occupation of a new niche, the chicken liver.

| S-EPMC5554493 | biostudies-literature

Campylobacter hepaticus, the Cause of Spotty Liver Disease in Chickens: Transmission and Routes of Infection.

Project description:The epidemiology of Spotty Liver Disease (SLD) was investigated by assaying 1,840 samples collected from layer chickens and the environment in poultry farms across Australia for the presence of Campylobacter hepaticus, the agent responsible SLD in chickens. A C. hepaticus specific PCR and bacterial culture were used. Results showed that birds could be infected with C. hepaticus up to 8 weeks before clinical SLD was manifested. In addition, birds could be infected long before laying starts, as young as 12 weeks old, but the peak period for SLD outbreaks was when the birds were 26-27 weeks old. Campylobacter hepaticus DNA was detected in motile organisms such as wild birds and rats and so these organisms may be vectors for C. hepaticus dissemination. Moreover, water, soil, mites, flies, and dust samples from SLD infected farms were also found to be PCR-positive for C. hepaticus DNA. However, it still remains to be determined whether these environmental sources carry any viable C. hepaticus. The indications from this study are that environmental sources are a likely transmission source of C. hepaticus. Therefore, biosecurity practices need to be strictly followed to prevent the spread of SLD amongst and between flocks. Also, a rapid, molecular detection method such as PCR should be used as to monitor for C. hepaticus presence in flocks before clinical disease is apparent, and therefore inform the use of biosecurity and therapeutic measures to help prevent SLD outbreaks.

| S-EPMC6974796 | biostudies-literature

Corrigendum: Genome Reduction for Niche Association in Campylobacter Hepaticus, A Cause of Spotty Liver Disease in Poultry.

Project description:[This corrects the article on p. 354 in vol. 7, PMID: 28848714.].

| S-EPMC5694627 | biostudies-literature

Characterization of a Novel Complete-Genome Sequence of a Galliform Chaphamaparvovirus from a Free-Range Laying Chicken Clinically Diagnosed with Spotty Liver Disease.

Project description:This study reports a novel complete genome of galliform chaphamaparvovirus 4, which was detected in the bile of a free-range laying chicken diagnosed with spotty liver disease. The genome was 4,367 bp in length, enclosed by two identical inverted terminal repeats. The detection of this novel chaphamaparvovirus represents a notable concern for the poultry industry in Australia.

| S-EPMC9670884 | biostudies-literature

Complete Genome Sequence of Campylobacter hepaticus Strain UF2019SK1, Isolated from a Commercial Layer Flock in the United States.

Project description:The thermophilic Campylobacter species Campylobacter hepaticus is the causative agent of spotty liver disease (SLD) in chickens. This announcement describes the complete genome sequence of C. hepaticus strain UF2019SK1, isolated from the liver of a commercial layer chicken with SLD in the United States.

| S-EPMC7996467 | biostudies-literature

Complete Genome Sequence and Annotation of Campylobacter jejuni YH003, Isolated from Retail Chicken.

Project description:The complete genome sequence of Campylobacter jejuni YH003, isolated from retail chicken, was determined using PacBio and Illumina technologies. The assembled genome is 1,743,985?bp (G+C content of 30.3%). Genome annotation revealed several genes encoding virulence and antibiotic resistance factors, including a type VI secretion system, cytolethal distending toxins, and a multidrug efflux system.

| S-EPMC6979299 | biostudies-literature

Complete Genome Sequences of Plasmid-Bearing Campylobacter coli and Campylobacter jejuni Strains Isolated from Retail Chicken Liver.

Project description:Complete genome sequences of Campylobacter coli strains WA333, YF2105, BG2108, MG1116, and BP3183 and Campylobacter jejuni strain IF1100 isolated from retail chicken liver showed the presence of 1,841,551-, 1,687,232-, 1,695,638-, 1,665,146-, 1,695,360-, and 1,744,171-bp circular chromosomes, respectively. These isolates also contained plasmids ranging in size from 5,209 to 55,122 bp.

| S-EPMC5721142 | biostudies-literature

The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus.

Project description:Helicobacter hepaticus causes chronic hepatitis and liver cancer in mice. It is the prototype enterohepatic Helicobacter species and a close relative of Helicobacter pylori, also a recognized carcinogen. Here we report the complete genome sequence of H. hepaticus ATCC51449. H. hepaticus has a circular chromosome of 1,799,146 base pairs, predicted to encode 1,875 proteins. A total of 938, 953, and 821 proteins have orthologs in H. pylori, Campylobacter jejuni, and both pathogens, respectively. H. hepaticus lacks orthologs of most known H. pylori virulence factors, including adhesins, the VacA cytotoxin, and almost all cag pathogenicity island proteins, but has orthologs of the C. jejuni adhesin PEB1 and the cytolethal distending toxin (CDT). The genome contains a 71-kb genomic island (HHGI1) and several genomic islets whose G+C content differs from the rest of the genome. HHGI1 encodes three basic components of a type IV secretion system and other virulence protein homologs, suggesting a role of HHGI1 in pathogenicity. The genomic variability of H. hepaticus was assessed by comparing the genomes of 12 H. hepaticus strains with the sequenced genome by microarray hybridization. Although five strains, including all those known to have caused liver disease, were indistinguishable from ATCC51449, other strains lacked between 85 and 229 genes, including large parts of HHGI1, demonstrating extensive variation of genome content within the species.

| S-EPMC164685 | biostudies-literature

Complete Genome Sequences of Campylobacter jejuni Strains Isolated from Retail Chicken and Chicken Gizzards.

Project description:Genome sequences of Campylobacter jejuni FJ3124 and ZP3204 isolated from retail chicken gizzards and Campylobacter jejuni TS1218 isolated from retail chicken showed the presence of 1,694,324-, 1,763,161-, and 1,762,596-bp circular chromosomes, respectively. Campylobacter jejuni ZP3204 and TS1218 harbored large tetracycline resistance plasmids with type IV secretion systems.

| S-EPMC5701488 | biostudies-literature

Complete genome sequence of Campylobacter jejuni strain S3.

Project description:Campylobacter jejuni is one of the leading causes of bacterial gastroenteritis in the world; however, there is only one complete genome sequence of a poultry strain to date. Here we report the complete genome sequence and annotation of the second poultry strain, C. jejuni strain S3. This strain has been shown to be nonmotile, to be a poor invader in vitro, and to be a poor colonizer of poultry after minimal in vitro passage.

| S-EPMC3067632 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data