Modified Significance Analysis of Microarrays in Heterogeneous Diseases.
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ABSTRACT:
SUBMITTER: Tzeng IS
PROVIDER: S-EPMC7909396 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Modified Significance Analysis of Microarrays in Heterogeneous Diseases.
Journal of personalized medicine 20210120 2
Significance analysis of microarrays (SAM) provides researchers with a non-parametric score for each gene based on repeated measurements. However, it may lose certain power in general statistical tests to correctly detect differentially expressed genes (DEGs) which violate homogeneity. Monte Carlo simulation shows that the "half SAM score" can maintain type I error rates of about 0.05 based on assumptions of normal and non-normal distributions. The author found 265 DEGs using the half SAM scorin ...[more]
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