Ontology highlight
ABSTRACT:
SUBMITTER: Kehl A
PROVIDER: S-EPMC7909816 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Kehl Alexandra A Haaland Anita Haug AH Langbein-Detsch Ines I Mueller Elisabeth E
Genes 20210121 2
Hemophilia A is the most common coagulation factor disorder in humans and dogs. The disease is characterized by the lack or diminished activity of Factor VIII (FVIII), caused by variants in the <i>F8</i> gene and inherited as an X chromosomal trait. Two related male Rhodesian Ridgebacks were diagnosed with Hemophilia A due to reduced FVIII activity. The purpose of the study was to determine the genetic cause and give breeding advice for the remaining family members in order to eradicate the vari ...[more]