Dataset Information

Volume and Mass Doubling Time of Lung Adenocarcinoma according to WHO Histologic Classification.

ABSTRACT:

Objective

This study aimed to evaluate the tumor doubling time of invasive lung adenocarcinoma according to the International Association of the Study for Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) histologic classification.

Materials and methods

Among the 2905 patients with surgically resected lung adenocarcinoma, we retrospectively included 172 patients (mean age, 65.6 ± 9.0 years) who had paired thin-section non-contrast chest computed tomography (CT) scans at least 84 days apart with the same CT parameters, along with 10 patients with squamous cell carcinoma (mean age, 70.9 ± 7.4 years) for comparison. Three-dimensional semiautomatic segmentation of nodules was performed to calculate the volume doubling time (VDT), mass doubling time (MDT), and specific growth rate (SGR) of volume and mass. Multivariate linear regression, one-way analysis of variance, and receiver operating characteristic curve analyses were performed.

Results

The median VDT and MDT of lung cancers were as follows: acinar, 603.2 and 639.5 days; lepidic, 1140.6 and 970.1 days; solid/micropapillary, 232.7 and 221.8 days; papillary, 599.0 and 624.3 days; invasive mucinous, 440.7 and 438.2 days; and squamous cell carcinoma, 149.1 and 146.1 days, respectively. The adjusted SGR of volume and mass of the solid-/micropapillary-predominant subtypes were significantly shorter than those of the acinar-, lepidic-, and papillary-predominant subtypes. The histologic subtype was independently associated with tumor doubling time. A VDT of 465.2 days and an MDT of 437.5 days yielded areas under the curve of 0.791 and 0.795, respectively, for distinguishing solid-/micropapillary-predominant subtypes from other subtypes of lung adenocarcinoma.

Conclusion

The tumor doubling time of invasive lung adenocarcinoma differed according to the IASCL/ATS/ERS histologic classification.

SUBMITTER: Hong JH

PROVIDER: S-EPMC7909861 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Volume and Mass Doubling Time of Lung Adenocarcinoma according to WHO Histologic Classification.

Hong Jung Hee JH Park Samina S Kim Hyungjin H Goo Jin Mo JM Park In Kyu IK Kang Chang Hyun CH Kim Young Tae YT Yoon Soon Ho SH

Korean journal of radiology 20201030 3

<h4>Objective</h4>This study aimed to evaluate the tumor doubling time of invasive lung adenocarcinoma according to the International Association of the Study for Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) histologic classification.<h4>Materials and methods</h4>Among the 2905 patients with surgically resected lung adenocarcinoma, we retrospectively included 172 patients (mean age, 65.6 ± 9.0 years) who had paired thin-section non-contrast chest compute ...[more]

PMID: 33169551

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Dataset Information

Volume and Mass Doubling Time of Lung Adenocarcinoma according to WHO Histologic Classification.

Objective

Materials and methods

Results

Conclusion

Publications

Volume and Mass Doubling Time of Lung Adenocarcinoma according to WHO Histologic Classification.

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