Ontology highlight
ABSTRACT:
SUBMITTER: Cachot A
PROVIDER: S-EPMC7909889 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Cachot Amélie A Bilous Mariia M Liu Yen-Cheng YC Li Xiaokang X Saillard Margaux M Cenerenti Mara M Rockinger Georg Alexander GA Wyss Tania T Guillaume Philippe P Schmidt Julien J Genolet Raphaël R Ercolano Giuseppe G Protti Maria Pia MP Reith Walter W Ioannidou Kalliopi K de Leval Laurence L Trapani Joseph A JA Coukos George G Harari Alexandre A Speiser Daniel E DE Mathis Alexander A Gfeller David D Altug Hatice H Romero Pedro P Jandus Camilla C
Science advances 20210226 9
CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover, their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining single-cell RNA-seq datasets, we identified CD4 T cell clusters displaying cytotoxic phenotypes in different human cancers, resembling CD8 T cell profiles. Using the peptide-MHCII-multimer technology, we confirmed ex vivo the presence of cytolytic tumor-specific CD4 T cells. We performed an integrated phenotypic an ...[more]