Ontology highlight
ABSTRACT:
SUBMITTER: Bailey AL
PROVIDER: S-EPMC7909907 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
JACC. Basic to translational science 20210226 4
There is ongoing debate as to whether cardiac complications of coronavirus disease-2019 (COVID-19) result from myocardial viral infection or are secondary to systemic inflammation and/or thrombosis. We provide evidence that cardiomyocytes are infected in patients with COVID-19 myocarditis and are susceptible to severe acute respiratory syndrome coronavirus 2. We establish an engineered heart tissue model of COVID-19 myocardial pathology, define mechanisms of viral pathogenesis, and demonstrate t ...[more]