Ontology highlight
ABSTRACT:
SUBMITTER: Zahm JA
PROVIDER: S-EPMC7909949 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Zahm Jacob A JA Stewart Michael G MG Carrier Joseph S JS Harrison Stephen C SC Miller Matthew P MP
eLife 20210216
Chromosome segregation during cell division requires engagement of kinetochores of sister chromatids with microtubules emanating from opposite poles. As the corresponding microtubules shorten, these 'bioriented' sister kinetochores experience tension-dependent stabilization of microtubule attachments. The yeast XMAP215 family member and microtubule polymerase, Stu2, associates with kinetochores and contributes to tension-dependent stabilization in vitro. We show here that a C-terminal segment of ...[more]