Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC7909951 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Yang Haibin H Lin Leishu L Sun Kang K Zhang Ting T Chen Wan W Li Lianghui L Xie Yuchen Y Wu Chuanyue C Wei Zhiyi Z Yu Cong C
eLife 20210215
Communications between actin filaments and integrin-mediated focal adhesion (FA) are crucial for cell adhesion and migration. As a core platform to organize FA proteins, the tripartite ILK/PINCH/Parvin (IPP) complex interacts with actin filaments to regulate the cytoskeleton-FA crosstalk. Rsu1, a Ras suppressor, is enriched in FA through PINCH1 and plays important roles in regulating F-actin structures. Here, we solved crystal structures of the Rsu1/PINCH1 complex, in which the leucine-rich-repe ...[more]