Ontology highlight
ABSTRACT:
SUBMITTER: Mahoney H
PROVIDER: S-EPMC7910436 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Mahoney Heather H Peterson Emily E Justin Hannah H Gonzalez David D Cardona Christopher C Stevanovic Korey K Faulkner John J Yunus Amara A Portugues Alexandra A Henriksen Amy A Burns Camden C McNeill Cameron C Gamsby Joshua J Gulick Danielle D
Scientific reports 20210226 1
Time-of-day effects have been noted in a wide variety of cognitive behavioral tests, and perturbation of the circadian system, either at the level of the master clock in the SCN or downstream, impairs hippocampus-dependent learning and memory. A number of kinases, including the serine-threonine casein kinase 1 (CK1) isoforms CK1δ/ε, regulate the timing of the circadian period through post-translational modification of clock proteins. Modulation of these circadian kinases presents a novel treatme ...[more]