Ontology highlight
ABSTRACT:
SUBMITTER: Fang R
PROVIDER: S-EPMC7910485 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Fang Rongxin R Preissl Sebastian S Li Yang Y Hou Xiaomeng X Lucero Jacinta J Wang Xinxin X Motamedi Amir A Shiau Andrew K AK Zhou Xinzhu X Xie Fangming F Mukamel Eran A EA Zhang Kai K Zhang Yanxiao Y Behrens M Margarita MM Ecker Joseph R JR Ren Bing B
Nature communications 20210226 1
Identification of the cis-regulatory elements controlling cell-type specific gene expression patterns is essential for understanding the origin of cellular diversity. Conventional assays to map regulatory elements via open chromatin analysis of primary tissues is hindered by sample heterogeneity. Single cell analysis of accessible chromatin (scATAC-seq) can overcome this limitation. However, the high-level noise of each single cell profile and the large volume of data pose unique computational c ...[more]