Unknown

Dataset Information

0

Monoterpenoids from the Fruits of Amomum tsao-ko Have Inhibitory Effects on Nitric Oxide Production.

ABSTRACT: In our search for novel plant-derived inhibitors of nitric oxide (NO) with potential for treating inflammatory diseases, the phytochemicals of Amomum tsao-ko fruits were investigated, leading to the isolation of one bicyclic nonane (1), three menthene skeleton monoterpenoids (2-4), and two acyclic monoterpenoids (5 and 6). Their structures were identified using one- and two-dimensional nuclear magnetic resonance spectroscopy, and mass spectrometry. To the best of our knowledge, compounds 2-5 were obtained from the genus Amomum for the first time. All isolates were tested for their ability to inhibit lipopolysaccharide-stimulated NO overproduction in RAW264.7 cells. Compound 4 was found to inhibit NO production. Western blotting analysis indicated that active compound 4 can regulate inducible NO synthase expression. In addition, lipopolysaccharide-induced interleukin 1 beta and interleukin-6 overproduction was reduced in a concentration-dependent manner.

SUBMITTER: Hong SS 

PROVIDER: S-EPMC7911220 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Monoterpenoids from the Fruits of <i>Amomum tsao-ko</i> Have Inhibitory Effects on Nitric Oxide Production.

Hong Seong Su SS   Lee Ji Eun JE   Jung Yeon Woo YW   Park Ju-Hyoung JH   Lee Jung A JA   Jeong Wonsik W   Ahn Eun-Kyung EK   Choi Chun Whan CW   Oh Joa Sub JS  

Plants (Basel, Switzerland) 20210128 2

In our search for novel plant-derived inhibitors of nitric oxide (NO) with potential for treating inflammatory diseases, the phytochemicals of <i>Amomum tsao-ko</i> fruits were investigated, leading to the isolation of one bicyclic nonane (<b>1</b>), three menthene skeleton monoterpenoids (<b>2</b>-<b>4</b>), and two acyclic monoterpenoids (<b>5</b> and <b>6</b>). Their structures were identified using one- and two-dimensional nuclear magnetic resonance spectroscopy, and mass spectrometry. To th  ...[more]

Similar Datasets

Unknown Tsaokoic Acid: A New Bicyclic Nonene from the Fruits of <i>Amomum tsao-ko</i> with Acetylcholinesterase Inhibitory Activity.
| S-EPMC10059965 | biostudies-literature
Unknown The complete chloroplast genome of <i>Amomum tsao-ko</i>.
| S-EPMC7748665 | biostudies-literature
Unknown Comparison of metabolites and variety authentication of Amomum tsao-ko and Amomum paratsao-ko using GC-MS and NIR spectroscopy.
| S-EPMC8313684 | biostudies-literature
Unknown Genome Sequencing of <i>Amomum tsao-ko</i> Provides Novel Insight Into Its Volatile Component Biosynthesis.
| S-EPMC9198571 | biostudies-literature
Unknown <i>Amomum tsao-ko</i> Crevost & Lemarie: a comprehensive review on traditional uses, botany, phytochemistry, and pharmacology.
| S-EPMC8743105 | biostudies-literature
Unknown Effects of Different Pre-drying and Drying Methods on Volatile Compounds in the Pericarp and Kernel of <i>Amomum tsao-ko</i>.
| S-EPMC8914167 | biostudies-literature
Unknown Development of 23 novel microsatellite markers of Amomum tsao-ko (Zingiberaceae) based on restriction-site-associated DNA sequencing.
| S-EPMC7811684 | biostudies-literature
Unknown Chromosome-level genome assembly of <i>Amomum tsao-ko</i> provides insights into the biosynthesis of flavor compounds.
| S-EPMC9719038 | biostudies-literature
Unknown Improvement of Obesity and Dyslipidemic Activity of Amomum tsao-ko in C57BL/6 Mice Fed a High-Carbohydrate Diet.
| S-EPMC7998585 | biostudies-literature
Unknown <i>Amomum tsao-ko</i> essential oil, a novel anti-COVID-19 Omicron spike protein natural products: A computational study.
| S-EPMC9014638 | biostudies-literature