An Update on Self-Amplifying mRNA Vaccine Development.
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ABSTRACT:
SUBMITTER: Blakney AK
PROVIDER: S-EPMC7911542 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
An Update on Self-Amplifying mRNA Vaccine Development.
Blakney Anna K AK Ip Shell S Geall Andrew J AJ
Vaccines 20210128 2
This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects. ...[more]
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