Dataset Information

Mortality, Severity, and Hospital Admission among COVID-19 Patients with ACEI/ARB Use: A Meta-Analysis Stratifying Countries Based on Response to the First Wave of the Pandemic.

ABSTRACT:

Background

The use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is controversial for treating COVID-19 patients. We aimed to estimate pooled risks of mortality, disease severity, and hospitalization associated with ACEI/ARB use and stratify them by country and country clusters.

Methods

We conducted a search in various databases through 4 July 2020 and then applied random-effects models to estimate pooled risks (OR_p) across stratifications by country cluster. Clusters were chosen to reflect outbreak times (China followed by Korea/Italy, others subsequently) and mobility restrictions (China and Denmark/France/Spain with stricter lockdowns than the UK/US).

Results

Overall analysis showed no increase in mortality; however, a statistical increase in mortality was seen in the US/UK cluster with OR_p = 1.28 [95% CI = 1.04; 1.56] and a decrease in China with OR_p = 0.65 [95% CI = 0.43; 0.96] and France with OR = 0.31 [95% CI = 0.14; 0.69]. Severity and hospitalization were not statistically significant in the analysis; however, several associations were seen in specific countries but not in country clusters.

Conclusion

The country-cluster meta-analysis provided a reasonable explanation for COVID-19 mortality among ACEI/ARB users. The analysis did not explain differences in severity and suggested the involvement of other factors. Hospitalization findings among ACEI/ARB users may be considered informative as they may have been subjected to clinical decisions and hospital-bed availability.

SUBMITTER: Alamer AA

PROVIDER: S-EPMC7912160 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Mortality, Severity, and Hospital Admission among COVID-19 Patients with ACEI/ARB Use: A Meta-Analysis Stratifying Countries Based on Response to the First Wave of the Pandemic.

Alamer Ahmad A AA Almulhim Abdulaziz S AS Alrashed Ahmed A AA Abraham Ivo I

Healthcare (Basel, Switzerland) 20210128 2

<h4>Background</h4>The use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is controversial for treating COVID-19 patients. We aimed to estimate pooled risks of mortality, disease severity, and hospitalization associated with ACEI/ARB use and stratify them by country and country clusters.<h4>Methods</h4>We conducted a search in various databases through 4 July 2020 and then applied random-effects models to estimate pooled risks (OR<sub>p</sub>) across ...[more]

PMID: 33525596

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Dataset Information

Mortality, Severity, and Hospital Admission among COVID-19 Patients with ACEI/ARB Use: A Meta-Analysis Stratifying Countries Based on Response to the First Wave of the Pandemic.

Background

Methods

Results

Conclusion

Publications

Mortality, Severity, and Hospital Admission among COVID-19 Patients with ACEI/ARB Use: A Meta-Analysis Stratifying Countries Based on Response to the First Wave of the Pandemic.

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