Ontology highlight
ABSTRACT:
SUBMITTER: Kamihira R
PROVIDER: S-EPMC7912572 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Marine drugs 20210131 2
A number of bioactive marine natural products have been isolated so far, but it is still difficult to disclose their modes of action. In this study, we prepared fluorescently labeled chemical probes from the cytotoxic marine cyclic peptides kapakahines A (<b>1</b>) and F (<b>2</b>) to visualize their localization as the first step of the study of their modes of action. We used fluorescent dyes <b>3a</b> or <b>3a/b</b> (a 1:1 mixture of <b>3a</b> and <b>3b</b>) whose terminal <i>N</i>-hydroxysucc ...[more]