Ontology highlight
ABSTRACT:
SUBMITTER: Huesa J
PROVIDER: S-EPMC7913699 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Huesa Juanjo J Giner-Lamia Joaquín J Pucciarelli M Graciela MG Paredes-Martínez Francisco F García-del Portillo Francisco F Marina Alberto A Casino Patricia P
Nucleic acids research 20210201 4
RcsB is a transcriptional regulator that controls expression of numerous genes in enteric bacteria. RcsB accomplishes this role alone or in combination with auxiliary transcriptional factors independently or dependently of phosphorylation. To understand the mechanisms by which RcsB regulates such large number of genes, we performed structural studies as well as in vitro and in vivo functional studies with different RcsB variants. Our structural data reveal that RcsB binds promoters of target gen ...[more]