Ontology highlight
ABSTRACT:
SUBMITTER: Seyedabadi M
PROVIDER: S-EPMC7913897 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Biomolecules 20210204 2
Arrestins are a small family of four proteins in most vertebrates that bind hundreds of different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three functions: precluding further receptor coupling to G proteins, facilitating receptor internalization, and initiating distinct arrestin-mediated signaling. The molecular mechanism of arrestin-GPCR interactions has been extensively studied and discussed from the "arrestin perspective", focusing on the roles of arrestin ...[more]