Increasing cancer risk over calendar year in people with multiple sclerosis: a case-control study.
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ABSTRACT: Background
Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients.Methods
Nested case-control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS patients and 39,448 controls matched by sex, age, general practitioner, and registration year. Cancer rates were compared using multivariable Cox regression models. Ethics approval was not required.Results
Cancer was reported in 433 (4.41%) MS patients and 2014 (5.31%) controls after index date. Cancer risk was associated with gender (HR for female?=?0.88, 95% CI?=?0.81-0.96, p?=?0.004), age at index date (HR?=?1.06, 95% CI?=?1.06-1.07, p?ConclusionsOverall cancer risk was similar in multiple sclerosis patients and matched controls. The frequency of cancer diagnoses has increased over time among MS patients but not in controls.
SUBMITTER: Zecca C
PROVIDER: S-EPMC7914231 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Increasing cancer risk over calendar year in people with multiple sclerosis: a case-control study.
Zecca Chiara C Disanto Giulio G Sacco Rosaria R MacLachlan Sharon S Kuhle Jens J Ramagopalan Sreeram V SV Gobbi Claudio C
Journal of neurology 20201021 3
<h4>Background</h4>Data on cancer prevalence and incidence in multiple sclerosis (MS) patients are controversial. This study is aimed at estimating cancer risk in MS patients.<h4>Methods</h4>Nested case-control study using data collected between 01/01/1987 and 28/02/2016 from the United Kingdom Clinical Practice Research Datalink. Cancer diagnoses after first MS code (index date) was counted in 10,204 MS patients and 39,448 controls matched by sex, age, general practitioner, and registration yea ...[more]
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