Different Roles of Mitochondria in Cell Death and Inflammation: Focusing on Mitochondrial Quality Control in Ischemic Stroke and Reperfusion.
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ABSTRACT:
SUBMITTER: Carinci M
PROVIDER: S-EPMC7914955 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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Different Roles of Mitochondria in Cell Death and Inflammation: Focusing on Mitochondrial Quality Control in Ischemic Stroke and Reperfusion.
Carinci Marianna M Vezzani Bianca B Patergnani Simone S Ludewig Peter P Lessmann Katrin K Magnus Tim T Casetta Ilaria I Pugliatti Maura M Pinton Paolo P Giorgi Carlotta C
Biomedicines 20210209 2
Mitochondrial dysfunctions are among the main hallmarks of several brain diseases, including ischemic stroke. An insufficient supply of oxygen and glucose in brain cells, primarily neurons, triggers a cascade of events in which mitochondria are the leading characters. Mitochondrial calcium overload, reactive oxygen species (ROS) overproduction, mitochondrial permeability transition pore (mPTP) opening, and damage-associated molecular pattern (DAMP) release place mitochondria in the center of an ...[more]
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