Ontology highlight
ABSTRACT:
SUBMITTER: Luo M
PROVIDER: S-EPMC7915185 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20210208 4
Influenza outbreaks pose a serious threat to human health. Hemagglutinin (HA) is an important target for influenza virus entry inhibitors. In this study, we synthesized four pentacyclic triterpene conjugates with a sialylglycopeptide scaffold through the Cu(I)-catalyzed alkyne-azide cycloaddition reaction (CuAAC) and prepared affinity assays of these conjugates with two HAs, namely H1N1 (A/WSN/1933) and H5N1 (A/Hong Kong/483/97), respectively. With a dissociation constant (<i>K</i><sub>D</sub>) ...[more]