Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye.
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ABSTRACT:
SUBMITTER: Koponen S
PROVIDER: S-EPMC7915489 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye.
Koponen Sanna S Kokki Emmi E Kinnunen Kati K Ylä-Herttuala Seppo S
Pharmaceutics 20210205 2
Pathological vessel growth harms vision and may finally lead to vision loss. Anti-angiogenic gene therapy with viral vectors for ocular neovascularization has shown great promise in preclinical studies. Most of the studies have been conducted with different adeno-associated serotype vectors. In addition, adeno- and lentivirus vectors have been used. Therapy has been targeted towards blocking vascular endothelial growth factors or other pro-angiogenic factors. Clinical trials of intraocular gene ...[more]
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