Ontology highlight
ABSTRACT:
SUBMITTER: Jacobo-Albavera L
PROVIDER: S-EPMC7915494 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Jacobo-Albavera Leonor L Domínguez-Pérez Mayra M Medina-Leyte Diana Jhoseline DJ González-Garrido Antonia A Villarreal-Molina Teresa T
International journal of molecular sciences 20210205 4
Cholesterol homeostasis is essential in normal physiology of all cells. One of several proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 (ABCA1), a transmembrane protein widely expressed in many tissues. One of its main functions is the efflux of intracellular free cholesterol and phospholipids across the plasma membrane to combine with apolipoproteins, mainly apolipoprotein A-I (Apo A-I), forming nascent high-density lipoprotein-cholesterol (HDL-C) particle ...[more]