Ontology highlight
ABSTRACT:
SUBMITTER: Zhu M
PROVIDER: S-EPMC7915546 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Zhu Mojun M Jin Zhaohui Z Hubbard Joleen M JM
Cancers 20210206 4
Microsatellite instability (MSI) is a hallmark of genetic predisposition to DNA damage. It arises from either germline or somatic events leading to impaired function of the mismatch repair system. It can be detected via genetic sequencing or immunohistochemistry with relatively high concordance rates. The presence of MSI in a tumor reflects a high neoantigen load and predicts favorable treatment response to immune checkpoint inhibitors (ICIs). In gastrointestinal cancers, MSI is a predictive bio ...[more]