Ontology highlight
ABSTRACT:
SUBMITTER: Zeng H
PROVIDER: S-EPMC7915724 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Zeng Huang H Kang Shuangshuang S Zhang Yu Y Liu Ke K Yu Qian Q Li Ding D An Lin-Kun LK
International journal of molecular sciences 20210208 4
Vascular endothelial growth factor (VEGF) is an angiogenic growth factor and plays a key role in tumor progression. The C-rich DNA sequence of <i>VEGF</i> promoter can form i-motif structure, which is a potential target for the development of novel anticancer agents. However, there is a limited number of chemotypes as the selective ligands of <i>VEGF</i> promoter i-motif, which leaves much room for development. Herein, we report the discovery of the natural oleanolic acid scaffold as a novel che ...[more]