Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC7915867 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Xu Jimin J Berastegui-Cabrera Judith J Carretero-Ledesma Marta M Chen Haiying H Xue Yu Y Wold Eric A EA Pachón Jerónimo J Zhou Jia J Sánchez-Céspedes Javier J
International journal of molecular sciences 20210205 4
Human adenoviruses (HAdVs) display a wide range of tissue tropism and can cause an array of symptoms from mild respiratory illnesses to disseminated and life-threatening infections in immunocompromised individuals. However, no antiviral drug has been approved specifically for the treatment of HAdV infections. Herein, we report our continued efforts to optimize salicylamide derivatives and discover compound <b>16</b> (JMX0493) as a potent inhibitor of HAdV infection. Compound <b>16</b> displays s ...[more]