Ontology highlight
ABSTRACT:
SUBMITTER: McClurg O
PROVIDER: S-EPMC7916085 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
McClurg Oliver O Tinson Ryan R Troeberg Linda L
Pharmaceuticals (Basel, Switzerland) 20210205 2
Osteoarthritis is a common, degenerative joint disease with significant socio-economic impact worldwide. There are currently no disease-modifying drugs available to treat the disease, making this an important area of pharmaceutical research. In this review, we assessed approaches being explored to directly inhibit metalloproteinase-mediated cartilage degradation and to counteract cartilage damage by promoting growth factor-driven repair. Metalloproteinase-blocking antibodies are discussed, along ...[more]