Ontology highlight
ABSTRACT:
SUBMITTER: Carpenter VJ
PROVIDER: S-EPMC7916462 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Cancers 20210210 4
Senolytics represent a group of mechanistically diverse drugs that can eliminate senescent cells, both in tumors and in several aging-related pathologies. Consequently, senolytic use has been proposed as a potential adjuvant approach to improve the response to senescence-inducing conventional and targeted cancer therapies. Despite the unequivocal promise of senolytics, issues of universality, selectivity, resistance, and toxicity remain to be further clarified. In this review, we attempt to summ ...[more]