Ontology highlight
ABSTRACT:
SUBMITTER: Ridder DA
PROVIDER: S-EPMC7916936 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Ridder Dirk Andreas DA Schindeldecker Mario M Weinmann Arndt A Berndt Kristina K Urbansky Lana L Witzel Hagen Roland HR Heinrich Stefan S Roth Wilfried W Straub Beate Katharina BK
Cancers 20210211 4
Patients with hepatocellular carcinoma (HCC) have a highly variable clinical course. Therefore, there is an urgent need to identify new prognostic markers to determine prognosis and select specific therapies. Recently, it has been demonstrated that dysregulation of the urea cycle (UC) is a common phenomenon in multiple types of cancer. Upon UC dysregulation, nitrogen is diverted toward the multifunctional enzyme carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase (C ...[more]