Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen HM
PROVIDER: S-EPMC7917312 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Nguyen Hong-My HM Saha Dipongkor D
Oncolytic virotherapy 20210224
Glioblastoma (GBM) is a lethal primary malignant brain tumor with no current effective treatments. The recent emergence of immuno-virotherapy and FDA approval of T-VEC have generated a great expectation towards oncolytic herpes simplex viruses (oHSVs) as a promising treatment option for GBM. Since the generation and testing of the first genetically engineered oHSV in glioma in the early 1990s, oHSV-based therapies have shown a long way of great progress in terms of anti-GBM efficacy and safety, ...[more]